This R&D Briefing summarises the background and methodology of process mapping with examples to demonstrate the steps involved in regulatory, HTA and coverage processes for new medicines. Process maps have been created for more than 75 jurisdictions and are available on an online platform called CIRS Regulatory and Reimbursement Atlas. The Atlas serves as an educational and visual communication tool to facilitate the explanation and comparison of different jurisdictions to multiple stakeholders. It has also been used to address a number of research questions and some of these studies are discussed in this R&D Briefing.