CIRS Agenda_2015

Decision Making:

The CIRS-BRAT Framework

The CIRS-BRAT Framework comprises a set of principles, processes and tools to help decision makers select, organise, understand and communicate evidence for pharmaceutical benefit-risk decisions.

The Pharmaceutical Research and Manufacturers of America (PhRMA) have addressed the need for improved benefit-risk assessment by supporting the development of a structured, systematic and transparent approach.

In 2012, the work of the BRAT was transferred to CIRS and the tool has since been available for download at no cost to interested parties. In collaboration with Dr Bennett Levitan (J&J) and colleagues, an updated version of the tool which also includes a working example of the CIRS-BRAT software using a hypothetical triptan as an assessment case study has been developed and is available for download by following the link: CIRS-BRAT Framework Download